Publications

Accueil » Publications

Rebuilding what has been ruined: Navigating the impacts of child maltreatment for romantic relationships and friendships in emerging adulthood

Par : Sereena Pigeon, Mylène Fernet, Audrey Brassard, Rachel Langevin
Source : Child abuse & neglect - doi:10.1016/j.chiabu.2025.107478

CONCLUSIONS: Emerging adults described interpersonal challenges stemming from broken trust caused by CM and maintained by internal experiences of fear, longing, guilt, and shame. Coping through avoidance, isolation, and dominance over others further maintained distrust. However, emerging adults undertook a learning process, involving attempts to engage with others, recognize patterns of abuse, and practice behavioural changes. Future research should explore the role of chosen relationships,...

Sex differences in the prevalence and cardiometabolic risk profiles of steatotic liver disease: A Canadian Longitudinal Study on Aging analysis

Par : Jessica Burnside, Felice Cinque, Giada Sebastiani, Alnoor Ramji, Keyur Patel, Mark Swain, Sahar Saeed
Source : Canadian journal of public health = Revue canadienne de sante publique - doi:10.17269/s41997-025-01025-5

CONCLUSION: In this large Canadian cohort, we found significant sex differences in SLD burden and cardiometabolic features. Epidemiological assessments are necessary to improve preparedness for the significant projected increase in advanced liver disease.

Changing age profile and incidence of injecting drug use initiation among people in Australia who inject drugs: evidence from two national repeated cross-sectional studies

Par : Olivia Price, Lisa Maher, Amy Peacock, Farzaneh Zolala, Louisa Degenhardt, Paul Dietze, Sarah Larney, Seraina Agramunt, Samantha Colledge-Frisby, Bradley Mathers, Dan Lewer, Rachel Sutherland
Source : The Lancet regional health. Western Pacific - doi:10.1016/j.lanwpc.2025.101548

BACKGROUND: The age of people who inject drugs appears to be increasing in some high-income countries. We aimed to explore trends in the age of people injecting and recently starting to inject drugs in Australia, and to model incidence of initiation over time.

Identifying heterogeneity of treatment effect for antibiotic duration in bloodstream infection: an exploratory post-hoc analysis of the BALANCE randomised clinical trial

Par : Sean W X Ong, Ruxandra Pinto, Asgar Rishu, Steven Y C Tong, Robert J Commons, John M Conly, Gerald A Evans, Michael Fralick, Christopher Kandel, Philippe R S Lagacé-Wiens, Todd C Lee, Sylvain A Lother, Derek R MacFadden, John C Marshall, Valérie Martel-Laferrière, Michael Mayette, Emily G McDonald, John D Neary, Josef Prazak, Edward Raby, Adrian Regli, Benjamin A Rogers, Stephanie Smith, Linda R Taggart, Han Ting Wang, Terence Wuerz, Dafna Yahav, Paul J Young, Robert A Fowler, Nick Daneman, BALANCE trial consortium
Source : EClinicalMedicine - doi:10.1016/j.eclinm.2025.103195

BACKGROUND: The BALANCE trial demonstrated non-inferiority of 7 (vs 14) day antibiotic durations in patients with uncomplicated non-S. aureus/lugdunensis bacterial bloodstream infections (BSI). However, there may be patient subgroups who benefit from longer durations. We aimed to evaluate if bedside clinical decision rules could identify these subgroups.

Opposite Roles of IL-32α Versus IL-32β/γ Isoforms in Promoting Monocyte-Derived Osteoblast/Osteoclast Differentiation and Vascular Calcification in People with HIV

Par : Hardik Ramani, Aurélie Cleret-Buhot, Mohamed Sylla, Rémi Bunet, Florent Bertrand, Marc-Messier Peet, Carl Chartrand-Lefebvre, Benoit Trottier, Réjean Thomas, Jean-Pierre Routy, Claude Fortin, Valérie Martel-Laferrière, Manel Sadouni, Guy Cloutier, Louise Allard, Jorge R Kizer, Nicolas Chomont, Petronela Ancuta, David B Hanna, Robert C Kaplan, Mohammad-Ali Jenabian, Alan L Landay, Madeleine Durand, Mohamed El-Far, Cécile L Tremblay
Source : Cells - doi:10.3390/cells14070481

People with HIV (PWH) have an increased risk of developing cardiovascular disease (CVD). Our recent data demonstrated that the multi-isoform proinflammatory cytokine IL-32 is upregulated in PWH and is associated with arterial stiffness and subclinical atherosclerosis. However, the mechanisms by which IL-32 contributes to the pathogenesis of these diseases remain unclear. Here, we show that while the less expressed IL-32α isoform induces the differentiation of human classical monocytes into the...

Clinical and Immunologic Impact of CMV Coinfection Among Children Living With HIV in Canada

Par : Yves Fougère, Jason Brophy, Michael T Hawkes, Terry Lee, Lindy Samson, Soren Gantt, Mi-Suk Kang Dufour, Christian Renaud, Hinatea Dieumegard, Madeleine Aby Diallo, Jade Canape, Stanley Read, Ari Bitnun, Hugo Soudeyns, Fatima Kakkar, EPIC Study Group
Source : The Pediatric infectious disease journal - doi:10.1097/INF.0000000000004811

CONCLUSIONS: CMV coinfection is common among CLWH and is associated with distinct immunological changes despite the effective control of HIV replication with antiretroviral therapy. The long-term implications of these immunological perturbations require further investigation.

Exploring housing instability through a gender lens among people who inject drugs in Montreal, Canada

Par : Farzaneh Vakili, Stine Bordier Høj, Nanor Minoyan, Sasha Udhesister, Valérie Martel Laferrière, Julie Bruneau, Sarah Larney
Source : Drug and alcohol review - doi:10.1111/dar.14050

INTRODUCTION: Housing instability contributes to harm among people who inject drugs (PWID). We examined determinants of varying levels of housing instability and explored gender differences in housing instability and associated determinants among PWID.

Continuous digital cough monitoring during 6-month pulmonary tuberculosis treatment

Par : Mihaja Raberahona, Alexandra Zimmer, Rivonirina Andry Rakotoarivelo, Patrick Andriniaina Randrianarisoa, Garcia Rambeloson, Etienne Rakotomijoro, Christophe Elody Andry, Haingonirina Anique Razafindrakoto, Dera Andriantahiana, Mamy Jean de Dieu Randria, Niaina Rakotosamimanana, Simon Grandjean Lapierre
Source : ERJ open research - doi:10.1183/23120541.00655-2024

CONCLUSION: Cough counts rapidly drop during the intensive phase of PTB treatment and then slowly decrease to a low baseline level by the end of the treatment. Community-based CCM using digital technology is feasible in low-resource settings but requires evaluation of alternative approaches to overcome adherence issues and technical limitations (mobile internet and electricity availability).

Impact of mental health service use on the HIV care cascade among women

Par : Seerat Chawla, Angela Kaida, Marie-Josée Brouillette, Bluma Kleiner, Danièle Dubuc, Lashanda Skerritt, Ann N Burchell, Danielle Rouleau, Mona Loutfy, Alexandra de Pokomandy, Canadian HIV Women's Sexual and Reproductive Health Cohort Study (CHIWOS) research team
Source : HIV medicine - doi:10.1111/hiv.70008

CONCLUSIONS: Our findings demonstrate that linkage to mental health care has a positive impact on HIV care outcomes among women. Accessible mental health services may serve to improve both mental well-being and progression of these patients along the HIV care cascade, thereby achieving individual and public health goals.

Validation of the Canadian English and French Versions of the Fear of COVID-19 Scale in Quebec Nursing Staff

Par : Céline Gélinas, Marc-André Maheu-Cadotte, Élisabeth Di Nardo, Mélanie Lavoie-Tremblay, Maria Cecilia Gallani, Émilie Gosselin, Christine Maheu, Sylvie D Lambert, Melissa Richard-Lalonde, Eric Tchouaket Nguemeleu, José Côté
Source : International journal of environmental research and public health - doi:10.3390/ijerph22020297

Nursing staff have been at the forefront of the pandemic, reporting high traumatic stress and anxiety levels related to high fear of COVID-19. Recommendations from previous studies include using the Fear of COVID-19 Scale (FCV-19S) as a screening tool to identify any individuals who may benefit from targeted psychological support. Thus far, the accuracy of the Canadian English and French versions of FCV-19S to detect high levels of traumatic stress and anxiety symptoms has not been examined. The...

Oseltamivir Reduces 30-Day Mortality in Older Adults With Influenza: A Pooled Analysis From the 2012-2019 Serious Outcomes Surveillance Network of the Canadian Immunization Research Network

Par : Henrique Pott, Melissa K Andrew, Zachary Shaffelburg, Michaela K Nichols, Lingyun Ye, May ElSherif, Todd F Hatchette, Jason J LeBlanc, Ardith Ambrose, Guy Boivin, William Bowie, Jennie Johnstone, Kevin Katz, Phillipe Lagacé-Wiens, Mark Loeb, Anne McCarthy, Allison McGeer, Andre Poirier, Jeff Powis, David Richardson, Makeda Semret, Stephanie Smith, Daniel Smyth, Grant Stiver, Sylvie Trottier, Louis Valiquette, Duncan Webster, Shelly A McNeil
Source : Open forum infectious diseases - doi:10.1093/ofid/ofaf058

CONCLUSIONS: Oseltamivir significantly reduces mortality risk in older adults hospitalized with influenza, even when administered after 48 hours, independent of vaccination status. Clinical Trials Registration. NCT01517191.

Impact of SARS-CoV-2 vaccination and of seasonal variations on the innate immune inflammatory response

Par : Hend Jarras, Isalie Blais, Benjamin Goyer, Wilfried W Bazié, Henintsoa Rabezanahary, Mathieu Thériault, Kim Santerre, Marc-André Langlois, Jean-François Masson, Joelle N Pelletier, Nicholas Brousseau, Denis Boudreau, Sylvie Trottier, Mariana Baz, Caroline Gilbert
Source : Frontiers in immunology - doi:10.3389/fimmu.2024.1513717

INTRODUCTION: The innate immune response is an important first checkpoint in the evolution of an infection. Although adaptive immunity is generally considered the immune component that retains antigenic memory, innate immune responses can also be affected by previous stimulations. This study evaluated the impact of vaccination on innate cell activation by TLR7/8 agonist R848, as well as seasonal variations.

Association of MASLD Phenotypes With Liver Fibrosis in Hepatitis C: The Role of Cardiometabolic Risk Factors

Par : Wesal Elgretli, Mohamed Shengir, Solomon Sasson, Agnihotram V Ramanakumar, Felice Cinque, Luz Esther Ramos Ballestreros, Marc Deschenes, Phil Wong, Tianyan Chen, Nadine Kronfli, Sahar Saeed, Alexa Keeshan, Saniya Tandon, Curtis Cooper, Giada Sebastiani
Source : Journal of viral hepatitis - doi:10.1111/jvh.70004

Steatotic liver disease is prevalent among people with hepatitis C virus (HCV). The new definition of metabolic dysfunction-associated steatotic liver disease (MASLD) emphasises the metabolic drivers of steatosis and recognises its frequent coexistence with other chronic liver diseases, including HCV. We aimed to evaluate the association of coexisting MASLD and HCV with liver fibrosis. Individuals with HCV who underwent transient elastography (TE) with associated controlled attenuation parameter...

Characteristics of supervised injection site clients and factors associated with requiring overdose intervention, Montreal, Canada, 2018-2022

Par : Camille Zolopa, Thomas D Brothers, Pascale Leclerc, Jean-François Mary, Carole Morissette, Julie Bruneau, Natasha K Martin, Elaine Hyshka, Sarah Larney
Source : The International journal on drug policy - doi:10.1016/j.drugpo.2025.104711

CONCLUSION: Across four Montréal SIS, site visits with an overdose requiring intervention were associated with transgender identity, younger age, stable housing, intending to inject fentanyl, injecting less frequently than daily, injecting for either more than five years or less than a year, single site attendance, and injecting most often in a public place. Montréal SIS serve a diverse clientele who inject drugs, with differing risks of onsite overdose.

Telehomecare Monitoring for Patients Receiving Anticancer Oral Therapy: Protocol for a Mixed Methods Evaluability Study

Par : Dominique Tremblay, Thomas Joly-Mischlich, Annick Dufour, Marie-Claude Battista, Djamal Berbiche, José Côté, Marco Décelles, Catherine Forget, Brigitte Guérin, Manon Larivière, Frédéric Lemay, Manon Lemonde, Éric Maillet, Nathalie Moreau, Michel Pavic, Sara Soldera, Catherine Wilhelmy
Source : JMIR research protocols - doi:10.2196/63099

CONCLUSIONS: This study will clarify how, why, for whom, and under what conditions TM can complement current care models. Our evaluability assessment will help to address implementation complexities and better understand intervention-to-practice operationalization so that implementation might be adapted to contextual factors without potentially harmful or inequitable impacts on patients.

Author Correction: Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption

Par : Susan Pereira Ribeiro, Zachary Strongin, Hugo Soudeyns, Felipe Ten-Caten, Khader Ghneim, Gabriela Pacheco Sanchez, Giuliana Xavier de Medeiros, Perla Mariana Del Rio Estrada, Adam-Nicolas Pelletier, Timothy Hoang, Kevin Nguyen, Justin Harper, Sherrie Jean, Chelsea Wallace, Robert Balderas, Jeffrey D Lifson, Gopalan Raghunathan, Eric Rimmer, Cinthia V Pastuskovas, Guoxin Wu, Luca Micci, Ruy M Ribeiro, Chi Ngai Chan, Jacob D Estes, Guido Silvestri, Daniel M Gorman, Bonnie J Howell, Daria J Hazuda, Mirko Paiardini, Rafick P Sekaly
Source : Nature immunology - doi:10.1038/s41590-025-02079-w

No abstract

Distinct peripheral pro-inflammatory profile associated with tuberous sclerosis complex and epilepsy

Par : Renaud Balthazard, Rose-Marie Drouin-Engler, Samuel Bertrand, Faycal Zine-Eddine, Jimmy Li, Olivier Tastet, Audrey Daigneault, Victoria H Mamane, Gloria Gabrielle Ortega-Delgado, Alina Maria Sreng Flores, Daniel E Kaufmann, Philippe Major, Andrew A House, Laurent Létourneau-Guillon, Nathalie Arbour, Mark R Keezer, Catherine Larochelle
Source : Epilepsia - doi:10.1111/epi.18261

OBJECTIVE: Tuberous sclerosis complex (TSC) is a monogenetic disorder associated with sustained mechanistic target of rapamycin (mTOR) activation, leading to heterogeneous clinical manifestations. Epilepsy and renal angiomyolipoma are the most important causes of morbidity in adult people with TSC (pwTSC). mTOR is a key player in inflammation, which in turn could influence TSC-related clinical manifestations. Reliable biomarkers are lacking to monitor and predict evolution and response to...

Problematic gambling among the LGBTQIA2S + population in Canada: A quantitative study

Par : Magaly Brodeur, Natalia Muñoz Gómez, Nathalie Carrier, Pasquale Roberge, Julie-Christine Cotton, Eva Monson, Adèle Morvannou, Marie-Ève Poitras, Anaïs Lacasse, Didier Jutras-Aswad, Yves Couturier, Christine Loignon, Olivier Simon, Catherine Hudon
Source : Addictive behaviors - doi:10.1016/j.addbeh.2025.108257

BACKGROUND AND AIMS: LGBTQIA2S + populations are believed to be at higher risk of problem gambling due to their elevated rates of mental disorders and substance abuse compared to heterosexual and cisgender populations. However, little is known about these populations regarding their gambling practices in the Canadian context.

A prospective multi-site study to evaluate the performance and usability of an oral fluid-based HIV self-test in Canada

Par : Richard A Galli, Darshanand Maraj, Kristin McBain, Jason M Lo Hog Tian, Abbey McFarland, Wangari Tharao, Nontobeko P Nkala, Arlene Chan, Mark da Silva, Rejean Thomas, Anne-Fanny Vassal, Martin Lepage, Laurie Ireland, Mike Payne, Jared Starr, Chris Fraser, Marion Selfridge, Mona Loutfy, Roberta Halpenny, Nirubini Jeyarajah, Vanessa Tran, Tony Mazzulli, Sean B Rourke
Source : BMC public health - doi:10.1186/s12889-024-21228-8

BACKGROUND: Blood and oral fluid-based HIV self-tests are important for reaching the undiagnosed living with HIV. The study objectives were to evaluate the oral fluid-based OraQuick® HIV Self-Test (HIV-ST) performance in comparison to laboratory reference testing; determine if laypersons can correctly perform the HIV-ST; document if intended users can successfully interpret pre-made contrived positive, negative, and invalid results; and document if intended users can understand the key messages...

Voir tous les résultats