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Targeted exercises can improve biomechanical markers in individuals with knee osteoarthritis: A secondary analysis from a cluster randomized controlled trial

Par : Alix Cagnin, Manon Choinière, Nathalie J Bureau, Madeleine Durand, Neila Mezghani, Nathaly Gaudreault, Nicola Hagemeister
Source : The Knee - doi:10.1016/j.knee.2022.10.008

CONCLUSIONS: Results suggest that targeted exercises can improve biomechanical markers in knee OA patients compared with CPC treatment. Further studies are needed to confirm these findings and refine the biomechanical markers to address to maximize patients' clinical outcomes.

Differential immune transcriptomic profiles between vaccinated and resolved HCV reinfected subjects

Par : Sabrina Mazouz, Eduardo Salinas, Nathalie Bédard, Ali Filali, Omar Khedr, Leo Swadling, Mohamed S Abdel-Hakeem, Asiyah Siddique, Eleanor Barnes, Julie Bruneau, Arash Grakoui, Naglaa H Shoukry
Source : PLoS pathogens - doi:10.1371/journal.ppat.1010968

Successive episodes of hepatitis C virus (HCV) infection represent a unique natural rechallenge experiment to define correlates of long-term protective immunity and inform vaccine development. We applied a systems immunology approach to characterize longitudinal changes in the peripheral blood transcriptomic signatures in eight subjects who spontaneously resolved two successive HCV infections. Furthermore, we compared these signatures with those induced by an HCV T cell-based vaccine regimen. We...

The Relationship between Visceral Adiposity and Nonalcoholic Fatty Liver Disease Diagnosed by Controlled Attenuation Parameter in People with HIV: A Pilot Study

Par : Giada Sebastiani, Nathalie Paisible, Cecilia Costiniuk, Joseph Cox, Dana Kablawi, Marina B Klein, Nadine Kronfli, Jean-Pierre Routy, Julian Falutz, Bertrand Lebouché, Giovanni Guaraldi
Source : Diagnostics (Basel, Switzerland) - doi:10.3390/diagnostics12112590

CONCLUSIONS: NAFLD diagnosed by CAP is associated with VAT in PWH independently of anthropometric measures of obesity. CAP may be a potential diagnostic marker of visceral adiposity in the practice of HIV medicine.

Association between the development of sub-clinical cardiovascular disease and HIV reservoir markers in people with HIV on suppressive ART

Par : Isabelle Turcotte, Mohamed El-Far, Manel Sadouni, Carl Chartrand-Lefebvre, Ali Filali-Mouhim, Rémi Fromentin, Annie Chamberland, Mohammad-Ali Jenabian, Jean-Guy Baril, Benoit Trottier, Réjean Thomas, Cécile L Tremblay, Madeleine Durand, Nicolas Chomont
Source : Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - doi:10.1093/cid/ciac874

We report that PWH diagnosed with coronary artery atherosclerotic plaques display higher levels of HIV DNA compared to those without atherosclerotic plaques. In a multivariable prediction model that included 27 traditional and HIV-related risk factors, measures of HIV DNA were among the most important predictors of atherosclerotic plaque formation.

Evaluation of the performance of multiple immunoassay diagnostic platforms on the National Microbiology Laboratory SARS-CoV-2 National Serology Panel

Par : Antonia Dibernardo, Nikki Pl Toledo, Alyssia Robinson, Carla Osiowy, Elizabeth Giles, Jacqueline Day, L Robbin Lindsay, Michael A Drebot, Timothy F Booth, Tamara Pidduck, Ashley Baily, Carmen L Charlton, Graham Tipples, Jamil N Kanji, Gino Brochu, Amanda Lang, Christian Therrien, Mélina Bélanger-Collard, Sylvie-Nancy Beaulac, Brian M Gilfix, Guy Boivin, Marie-Ève Hamelin, Julie Carbonneau, Simon Lévesque, Philippe Martin, Andrés Finzi, Gabrielle Gendron-Lepage, Guillaume Goyette, Mehdi Benlarbi, Romain Gasser, Claude Fortin, Valérie Martel-Lafferrière, Myriam Lavoie, Renée Guérin, Louis-Patrick Haraoui, Christian Renaud, Craig Jenkins, Sheila F O'Brien, Steven J Drews, Valerie Conrod, Vanessa Tran, Bill Awrey, Robert Scheuermann, Alan DuPuis, Anne Payne, Casey Warszycki, Roxie Girardin, William Lee, George Zahariadis, Lei Jiao, Robert Needle, James Cordenbach, Jerry Zaharatos, Kellee Taylor, Marty Teltscher, Matthew Miller, May Elsherif, Peter Robertson, Jason L Robinson
Source : Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada - doi:10.3138/jammi-2021-0026

CONCLUSION: This proficiency study demonstrates that most of the SARS-CoV-2 serological assays utilized by provincial public health or hospital laboratories in Canada have acceptable sensitivity and excellent specificity.

Changes in supervised consumption site use and emergency interventions in Montréal, Canada in the first twelve months of the COVID-19 pandemic: An interrupted time series study

Par : Camille Zolopa, Thomas D Brothers, Pascale Leclerc, Jean-François Mary, Carole Morissette, Julie Bruneau, Elaine Hyshka, Natasha K Martin, Sarah Larney
Source : The International journal on drug policy - doi:10.1016/j.drugpo.2022.103894

CONCLUSION: Reduced SCS use and increasing emergency interventions at SCS are cause for serious concern. Findings suggest increased availability of novel synthetic opioids in Montréal, heightening overdose risk.

Trends in Use of Combination Antiretroviral Therapy and Treatment Response from 2000 to 2016 in the Canadian Observational Cohort (CANOC): A Longitudinal Cohort Study

Par : Alison R McClean, Jason Trigg, Claudette Cardinal, Mona Loutfy, Curtis Cooper, Abigail Kroch, Mostafa Shokoohi, Nimâ Machouf, Réjean Thomas, Marina B Klein, Deborah V Kelly, Alexander Wong, Stephen Sanche, Julio S G Montaner, Robert S Hogg
Source : The Canadian journal of hospital pharmacy - doi:10.4212/cjhp.3234

CONCLUSIONS: Concordance with treatment guidelines was demonstrated over time with respect to cART prescribing and immunologic and virologic response.

A boost with SARS-CoV-2 BNT162b2 mRNA vaccine elicits strong humoral responses independently of the interval between the first two doses

Par : Alexandra Tauzin, Shang Yu Gong, Debashree Chatterjee, Shilei Ding, Mark M Painter, Rishi R Goel, Guillaume Beaudoin-Bussières, Lorie Marchitto, Marianne Boutin, Annemarie Laumaea, James Okeny, Gabrielle Gendron-Lepage, Catherine Bourassa, Halima Medjahed, Guillaume Goyette, Justine C Williams, Yuxia Bo, Laurie Gokool, Chantal Morrisseau, Pascale Arlotto, Renée Bazin, Judith Fafard, Cécile Tremblay, Daniel E Kaufmann, Gaston De Serres, Jonathan Richard, Marceline Côté, Ralf Duerr, Valérie Martel-Laferrière, Allison R Greenplate, E John Wherry, Andrés Finzi
Source : Cell reports - doi:10.1016/j.celrep.2022.111554

Due to the recrudescence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections worldwide, mainly caused by the Omicron variant of concern (VOC) and its sub-lineages, several jurisdictions are administering an mRNA vaccine boost. Here, we analyze humoral responses induced after the second and third doses of an mRNA vaccine in naive and previously infected donors who received their second dose with an extended 16-week interval. We observe that the extended interval elicits...

Emerging Adults' Adverse Life Events and Psychological Functioning: A Comparison Based on Intergenerational Trajectories of Child Maltreatment

Par : Rachel Langevin, Audrey Kern, Mylène Fernet, Audrey Brassard
Source : Journal of interpersonal violence - doi:10.1177/08862605221127214

Intergenerational continuity of child maltreatment (CM) is a well-documented phenomenon of concern; however, its effects on the child's level of exposure to CM, as well as subsequent trauma exposure and adult functioning remain undocumented. The present study aimed to further explore the intergenerational effects of CM by comparing emerging adults (EA; ages 18-25) on their exposure to CM, adult victimization, and psychological functioning according to their mother's CM histories. One hundred and...

Association Between Markers of Vulnerability for Cannabis-Related Harms and Source of Supply: Secondary Analysis of a Representative Population Survey

Par : Sarah Drouin, Élie Rizkallah, Florence Conus, Sarah Larney, Navdeep Kaur, Codjo Djignefa Djade, Didier Jutras-Aswad
Source : Canadian journal of psychiatry. Revue canadienne de psychiatrie - doi:10.1177/07067437221128470

CONCLUSIONS: No association was detected between the source of cannabis supply and potential vulnerability indicators of cannabis-related harms, but SQDC consumers were more aware of the cannabinoid content of the products purchased. These results suggest that the regulated government supply in Quebec is reaching a substantial portion of those with potential high vulnerability to harm. Whether this knowledge translates into a reduction in the negative consequences related to consumption is still...

Immune checkpoint expression on HIV-specific CD4+ T cells and response to their blockade are dependent on lineage and function

Par : Elsa Brunet-Ratnasingham, Antigoni Morou, Mathieu Dubé, Julia Niessl, Amy E Baxter, Olivier Tastet, Nathalie Brassard, Gloria Ortega-Delgado, Roxanne Charlebois, Gordon J Freeman, Cécile Tremblay, Jean-Pierre Routy, Daniel E Kaufmann
Source : EBioMedicine - doi:10.1016/j.ebiom.2022.104254

BACKGROUND: Immune checkpoint blockade (ICB) partially reverses the dysfunctional state of antigen-specific T cell in chronic infections. However, its impact on the diverse subsets of CD4+ T cells in humans is largely unknown.

Experiences of Migrant People Living with HIV in a Multidisciplinary HIV Care Setting with Rapid B/F/TAF Initiation and Cost-Covered Treatment: The 'ASAP' Study

Par : Anish K Arora, Kim Engler, David Lessard, Nadine Kronfli, Adriana Rodriguez-Cruz, Edmundo Huerta, Benoit Lemire, Jean-Pierre Routy, René Wittmer, Joseph Cox, Alexandra de Pokomandy, Lina Del Balso, Marina Klein, Giada Sebastiani, Isabelle Vedel, Amélie Quesnel-Vallée, None Asap Migrant Advisory Committee, Bertrand Lebouché
Source : Journal of personalized medicine - doi:10.3390/jpm12091497

This study aimed to explore the experiences of migrant people living with HIV (MLWH) enrolled in a Montreal-based multidisciplinary HIV care clinic with rapid antiretroviral treatment (ART) initiation and cost-covered ART. Between February 2020 and March 2022, 32 interviews were conducted with 16 MLWH at three time-points (16 after 1 week of ART initiation, 8 after 24 weeks, 8 after 48 weeks). Interviews were analyzed via the Framework Method. Thirty categories were identified, capturing...

Measuring progress towards reaching zero new HIV acquisitions among key populations in Québec (Canada) using routine surveillance data: a mathematical modelling study

Par : Carla M Doyle, Joseph Cox, Rachael M Milwid, Raphaël Bitera, Charlotte Lanièce Delaunay, Michel Alary, Gilles Lambert, Cécile Tremblay, Sharmistha Mishra, Mathieu Maheu-Giroux
Source : Journal of the International AIDS Society - doi:10.1002/jia2.25994

CONCLUSIONS: HIV incidence has drastically decreased in MSM and PWID across Québec, alongside significant improvements in diagnosis and treatment coverage-and the 2013 introduction of pre-exposure prophylaxis. Despite this, HIV transmission continued. Effective efforts to halt this transmission and rapidly diagnose people who acquired HIV, especially among younger MSM, are needed to achieve elimination. Further, as the impacts of the COVID-19 pandemic on HIV transmission are understood,...

Humoral immune responses against SARS-CoV-2 Spike variants after mRNA vaccination in solid organ transplant recipients

Par : Alexandra Tauzin, Guillaume Beaudoin-Bussières, Shang Yu Gong, Debashree Chatterjee, Gabrielle Gendron-Lepage, Catherine Bourassa, Guillaume Goyette, Normand Racine, Zineb Khrifi, Julie Turgeon, Cécile Tremblay, Valérie Martel-Laferrière, Daniel E Kaufmann, Héloïse Cardinal, Marc Cloutier, Renée Bazin, Ralf Duerr, Mélanie Dieudé, Marie-Josée Hébert, Andrés Finzi
Source : iScience - doi:10.1016/j.isci.2022.104990

Although SARS-CoV-2 mRNA vaccination has been shown to be safe and effective in the general population, immunocompromised solid organ transplant recipients (SOTRs) were reported to have impaired immune responses after one or two doses of vaccine. In this study, we examined humoral responses induced after the second and the third dose of mRNA vaccine in different SOTR (kidney, liver, lung, and heart). Compared to a cohort of SARS-CoV-2 naïve immunocompetent health care workers (HCWs), the second...

Cannabinoids and Chronic Liver Diseases

Par : Ralph-Sydney Mboumba Bouassa, Giada Sebastiani, Vincenzo Di Marzo, Mohammad-Ali Jenabian, Cecilia T Costiniuk
Source : International journal of molecular sciences - doi:10.3390/ijms23169423

Nonalcoholic fatty liver disease (NAFLD), alcohol-induced liver disease (ALD), and viral hepatitis are the main causes of morbidity and mortality related to chronic liver diseases (CLDs) worldwide. New therapeutic approaches to prevent or reverse these liver disorders are thus emerging. Although their etiologies differ, these CLDs all have in common a significant dysregulation of liver metabolism that is closely linked to the perturbation of the hepatic endocannabinoid system (eCBS) and...

Current considerations for clinical management and care of non-alcoholic fatty liver disease: Insights from the 1st International Workshop of the Canadian NASH Network (CanNASH)

Par : Giada Sebastiani, Keyur Patel, Vlad Ratziu, Jordan J Feld, Brent A Neuschwander-Tetri, Massimo Pinzani, Salvatore Petta, Annalisa Berzigotti, Peter Metrakos, Naglaa Shoukry, Elizabeth M Brunt, An Tang, Jeremy F Cobbold, Jean-Marie Ekoe, Karen Seto, Peter Ghali, Stéphanie Chevalier, Quentin M Anstee, Heather Watson, Harpreet Bajaj, James Stone, Mark G Swain, Alnoor Ramji
Source : Canadian liver journal - doi:10.3138/canlivj-2021-0030

Non-alcoholic fatty liver disease (NAFLD) affects approximately 8 million Canadians. NAFLD refers to a disease spectrum ranging from bland steatosis to non-alcoholic steatohepatitis (NASH). Nearly 25% of patients with NAFLD develop NASH, which can progress to liver cirrhosis and related end-stage complications. Type 2 diabetes and obesity represent the main risk factors for the disease. The Canadian NASH Network is a national collaborative organization of health care professionals and...

Sex-Dependent Hepatoprotective Role of IL-22 Receptor Signaling in Non-Alcoholic Fatty Liver Disease-Related Fibrosis

Par : Mohamed N Abdelnabi, Manuel Flores Molina, Geneviève Soucy, Vincent Quoc-Huy Trinh, Nathalie Bédard, Sabrina Mazouz, Nathalie Jouvet, Jessica Dion, Sarah Tran, Marc Bilodeau, Jennifer L Estall, Naglaa H Shoukry
Source : Cellular and molecular gastroenterology and hepatology - doi:10.1016/j.jcmgh.2022.08.001

CONCLUSIONS: Our data suggest a sex-dependent hepatoprotective antiapoptotic effect of IL22-receptor signaling during NAFLD-related liver injury in females.

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